The Japanese giant hornet is large and can be very aggressive if provoked. Its venom, which is injected by the 6. 25 mm-long stinger, attacks the nervous system and damages the tissue of its victims. Tests involving mice found that the venom falls short of being the most lethal of wasp venom, having an LD50 of 4. 0 mg/kg. In comparison, the deadliest wasp venom (at least to lab mice) by weight belongs to Vespa luctuosa at 1. 6 mg/kg. The potency of the sting is due, rather, to the relatively large amount of venom injected. Being stung is extremely painful and can require hospitalization. Asian giant hornet stings can cause anaphylactic shock in allergic people but can still be lethal to people who are not allergic, provided the dose is sufficient. In China, where the hornet can also be found, the conventional wisdom is that people stung more than 10 times need medical help, and emergency treatment if stung more than 30 times. The stings can also cause renal failure. Thirty to forty people die in Japan every year after having been stung by bees and wasps (including the Japanese hornet).
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