Thrax assumes leadership of a gang of sweat germs and launches an attack on the mucus dam in Frank's nose, causing a runny nose, nearly expelling Ozzy and Drix before Frank inhales them back into the sinuses. While continuing the investigation, Drix hears Phlegmming accusing Ozzy of having the worst record in Frank's body and he doesn't want a repeat of the same when Frank is currently planning a trip to the chicken wing festival in Buffalo, New York. When he wonders aloud why Ozzy had a record, Ozzy reveals to Drix that two years ago, during a science fair at Shane's school, he caused Frank to publicly vomit on Shane's science and P. E. teacher, Mrs. Boyd (Molly Shannon), after seeing a deadly virus on an oyster Frank ate earlier after observing an oyster display thanks to a boy telling people to look at Frank moments before he vomited. The story ran in the newspaper the next day, resulting in Frank and Mrs. Boyd becoming the town laughingstock overnight causing them to be humiliated every year as well as Frank being fired from his job at the pea soup factory by his manager and supervisor after he embarrassed them. His brother, Shane's uncle Bob (Chris Elliott), later helped him get a job at the zoo, where Frank still gets zero respect. Ozzy, in turn, was then suspended from his job working in the stomach and kidneys and then demoted to patrol duty in the mouth for excessive use of unnecessary force. Ozzy tells Drix how he wonders every day if what he did was right since then. Drix, in turn, assures Ozzy that he did the right thing as raw oysters are frequently breeding grounds for potentially dangerous bacteria which is what Ozzy was trying to tell everybody.
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