The fictional universe depicted in the series is premised on the notion that vampires exist, unbeknownst to the majority of humans until two years before the series premiere, when the creation of synthetic blood ("Tru Blood") by Japanese scientists, which eliminated vampires' need for human blood to survive, allowed vampires to "come out of the coffin" and reveal their existence to the world. E-1 This so-called "Great Revelation" has split vampires into two camps: those who wish to integrate into human society (i. e. , "mainstream") by campaigning for citizenship and equal rights,E-1 and those who think human-vampire co-existence is impossible, because it conflicts with the inherently predatory and violent nature of vampires. It has also caused similar divisions amongst non-vampires; some believe that vampires should be accepted and granted rights, while others view them as monsters to be destroyed. Throughout the series, other supernatural creatures are introduced, among them shapeshifters, werewolves, faeries, witches, and a maenad.
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